Monday Night Football Week 4: Seahawks vs. Lions Picks, Predictions, & Best Player Props Bets

The Seahawks vs. Lions on Monday Night Football features two NFC champion hopefuls in the final game to cap off Week 4 of the NFL. 

Week 4 of the NFL season features an excellent Monday Night Football matchup with an undefeated team, but it’s not the one many picked to be undefeated heading into Week 4.

Seattle has looked the part of a 3-0 team, winning with a balance of gritty defense and a versatile offense. They’ve found a way to win, no matter the circumstances. But now, as they prepare to face the Lions, they encounter their most formidable challenge yet.

For Detroit, this game is about more than just keeping pace. It’s about proving themselves. Despite moments of brilliance, they haven’t quite strung together a complete, dominant game. With their talented roster and a home crowd behind them, this is their chance to make a statement.

Seahawks vs. Lions Betting Preview

All Seahawks vs. Lions odds are from DraftKings Sportsbook and are correct on Wednesday, Sept. 25.

• Spread
  Lions -4
• Moneyline
  Seahawks +175| Lions -210
• Over/Under
  46.5
• Game time
  8:15 p.m. ET
• Location
  Ford Field | Detroit, Michigan
• Predicted Weather at Kick
  72 degrees, Partly Cloudy
• How to Watch
  ABC

Check out all of our NFL picks and best picks here! 

Seahawks vs. Lions Picks, Predictions, and Best Player Prop Bets

The Detroit Lions enter Week 4 with a 2-1 record, a plus-nine scoring differential, and a team poised to take the next step. They’ve faced relatively strong competition, squaring off against the Rams, Buccaneers, and Cardinals. Yet, despite their early success, the Lions have left a lot on the table — especially in the red zone.

Scoring touchdowns on just 38% of their red-zone trips, Detroit has struggled to cash in when it matters most, ranking 26th in the NFL in this category. It’s a surprising downturn for a team that finished second in red-zone efficiency last season.

If that regression hits in Week 4, the Lions could have a big day offensively against a Seattle defense that has shown cracks. While the Seahawks are 3-0, their wins came against underwhelming offenses, including the Patriots, Broncos, and a Dolphins team led by Skylar Thompson. Their defensive front has been porous, and that’s where Detroit may find its edge.

Even without standout center Frank Ragnow, the Lions’ rushing attack is poised to take advantage of Seattle’s injury-depleted front seven. David Montgomery’s bruising style — particularly his ability to break through first contact — could wear down Seattle’s linebackers and safeties. With Byron Murphy and Leonard Williams out, the Seahawks’ defensive line is vulnerable, especially in the B-gaps where Montgomery thrives.

Rookie Jahmyr Gibbs adds a dynamic element to the ground game, giving Detroit even more versatility and speed to exploit Seattle’s weaknesses.

Jared Goff Over/ Under 238.5 Passing Yards (-110)

Seattle’s strong defensive numbers come with an asterisk. They’ve faced quarterbacks from New England, Denver, and a Miami team led by Skylar Thompson. None of those offenses bring the firepower that Jared Goff and the Lions can offer. Goff is in a different class than the quarterbacks Seattle has faced so far, and he’ll be playing at home, where he’s thrived.

The home-field advantage for Goff is undeniable. Since the start of last season, he’s hit the over on his passing yards total in 11 of his previous 12 games at Ford Field. Since the beginning of 2022, Goff has only missed the mark twice. His home splits tell the story of a quarterback who is comfortable and dominant on his turf.

Shake it Goff

Jared Goff loves playing Seattle, throwing for 378 and 323 yards in his last two games against the Seahawks, as well as seven passing TDs in those games.

He’s also amongst a number of quarterbacks who have thrown more interceptions than touchdowns.

In 2024,… pic.twitter.com/VCEMqXwJRE

— Dan’s AI Sports Picks (@DanGambleAI) September 30, 2024

While Seattle’s defense has looked formidable against weaker competition, Goff’s track record at home, combined with the Lions’ offensive firepower, suggests this line is too low. Expect Goff to challenge Seattle’s secondary and push past this total, showing why he’s a tier above the quarterbacks they’ve faced.

I like his passing yards over prop.

Noah Fant Longest Reception Over/ Under 14.5 Yards (-115)

Geno Smith has already been sacked eight times in the first three games, and now he’s facing one of the most relentless pass rushes in the NFL. The pressure will be constant, and with Detroit’s defense excelling in coverage, particularly against tight ends, the challenges only increase for Seattle’s offense.

Detroit has been exceptional at limiting tight end production, allowing 2.5 receptions on 5.0 targets and a mere 27.7 yards per game through the air to the position. That doesn’t bode well for Noah Fant, who has already struggled to find his footing in Seattle’s offense this season. With just 85 receiving yards on nine catches (9.4 YPC) and a long of 16 yards, Fant has yet to be a consistent option.

Given the Lions’ ability to neutralize tight ends, Smith will likely look elsewhere for his downfield threats. When Seattle goes long, Metcalf, Smith-Njigba, or Lockett will draw Smith’s eye, leaving Fant to have a quieter day with the combination of Detroit’s pass rush and their tight end coverage.

I’ll take Fant’s longest reception UNDER 14.5 yards.

The Prediction: Lions 31 – Seahawks 17

Best Bets:

• Seahawks -4
• Jared Goff OVER 238.5 Passing Yards (-110)
• Noah Fant UNDER  14.5 Yards on Longest Reception (-115)